Skip to content
Chapter IV · Research & References Reference library Updated by Dr. Aronov

Research behind the components

Research, presented with context.

This reference library presents published research on individual compounds used in our infusions. All of the available literature examines oral use, and a few findings come from laboratory studies rather than human trials. Research on an individual compound—or on a different route of administration—does not establish the safety or effectiveness of a combined IV infusion. Each entry identifies the study type and route studied, when available, so readers can understand the context, relevance, and limitations of the findings.

0 References in the library
0 Infusions with published references on file
0 Research categories, labeled on every card

How to read the research

What kind of study was it?

Not all research provides the same level—or type—of evidence. Each research card below is labeled 01–06 to show what kind of study it was.

Important: A study of an ingredient taken as a pill is not the same as a study of that ingredient given by IV. IV administration bypasses digestion and delivers ingredients directly into the bloodstream. Unless a study specifically tested the IV form, its findings should not be assumed to prove the safety or benefits of an IV infusion.

  1. RESEARCH CATEGORY 01

    Several studies reviewed together

    Systematic review or meta-analysis

    Researchers gather and compare several studies that asked the same question. This can provide a bigger picture, but the answer is only as strong as the studies included.

  2. RESEARCH CATEGORY 02

    Study in people

    Human clinical study

    This research was done with people. Participants received an ingredient or treatment, and researchers measured what happened. Larger, well-designed studies usually give more dependable answers.

  3. RESEARCH CATEGORY 03

    Summary of earlier research

    Review article

    Experts reviewed and explained studies that had already been published. No new group of patients was studied. The summary depends on which studies were chosen and how strong those studies were.

  4. RESEARCH CATEGORY 04

    Study that looks for patterns

    Observational study

    Researchers looked at what happened in a group of people without choosing their care. The study may show that two things happened together, but it cannot prove that one caused the other.

  5. RESEARCH CATEGORY 05

    Animal or cell research

    Preclinical study

    This early research was done in animals or cells—not people. It may show how something could work, but the same result may not happen in people.

  6. RESEARCH CATEGORY 06

    Product label or supplier information

    This information comes from an official label, manufacturer, or supplier. It may tell us what is in the product, how it is used, and important warnings. It does not prove that a specific IV combination works for a wellness goal.

Research type
Infusion

Showing all 48 references

I — 5 references

Glutathione IV Injection

Glutathione · antioxidant · skin & cellular health

See the infusion
  1. 03 Peer-reviewed review

    Glutathione and its antiaging and antimelanogenic effects

    PubMed Read
  2. 01 Systematic review

    Glutathione in Skin Aging and Tissue Regeneration: A Systematic Review of Molecular Mechanisms, Redox Modulation, and Biomedical Implications

    PMC / NIH Read
  3. 03 Scientific review

    Glutathione in Skin Aging and Tissue Regeneration

    Describes glutathione as a regulator of redox balance, melanin production and cellular repair, and its study in dermatology for skin brightening, anti-aging and tissue regeneration.

    PubMed Read
  4. 03 Scientific review

    Glutathione as a Shared Host Factor in Tuberculosis and COVID-19

    Discusses glutathione’s role in immune function and oxidative stress across two infectious diseases. Studying an illness is how the biology is learned — it does not mean this infusion prevents or treats any infection.

    PubMed Read
  5. 02 Clinical study in people

    Glutathione Deficiency and Oxidative Stress in Hospitalized Adults With COVID-19

    Measured glutathione and oxidative stress in hospitalized patients. It describes an association in a specific hospitalized population; it does not evaluate this elective outpatient infusion.

    PubMed Read
II — 7 references

Antioxidant ×3 Reset IV

Vitamin C · glutathione · alpha-lipoic acid · antioxidant pathways

See the infusion
  1. 03 Critical appraisal

    Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

    PMC / NIH Read
  2. 02 Research study

    Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies

    PMC / NIH Read
  3. 03 Peer-reviewed review

    Glutathione Therapy in Diseases: Challenges and Potential Solutions for Therapeutic Advancement

    PubMed Read
  4. 04 Cross-sectional study

    Serum Vitamin C concentrations are inversely related to biological aging: a population-based cross-sectional study

    PMC / NIH Read
  5. 03 Peer-reviewed review

    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

    PMC / NIH Read
  6. 03 Scientific review

    Alpha-Lipoic Acid: Biological Mechanisms and Health Benefits

    This 2024 review describes the ALA/DHLA antioxidant system and its involvement in maintaining reduced forms of other antioxidants, including glutathione.

    PubMed Read
  7. 03 Scientific review

    The Pharmacology of the Antioxidant Lipoic Acid

    This review explains that reduced alpha-lipoic acid, known as DHLA, can help regenerate vitamin C and glutathione.

    PubMed Read
III — 8 references

Immun-O-Boost IV Supportive Infusion

Zinc · alpha-lipoic acid · glutathione · immune support

See the infusion
  1. 03 Peer-reviewed review

    The nutritional roles of zinc for immune system and COVID-19 patients

    Frontiers in Nutrition · 2024 Read
  2. 02 Clinical study

    Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection

    PubMed Read
  3. 03 Peer-reviewed review

    The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium

    PMC / NIH Read
  4. 03 Peer-reviewed review

    Recent Developments in the Understanding of Immunity, Pathogenesis and Management of COVID-19

    PMC / NIH Read
  5. 03 Peer-reviewed review

    The Role of Micronutrients in Support of the Immune Response against Viral Infections

    PMC / NIH Read
  6. 03 Peer-reviewed review

    Understanding How Minerals Contribute to Optimal Immune Function

    PMC / NIH Read
  7. 03 Peer-reviewed review

    The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19

    PubMed Read
  8. 01 Systematic review — different clinical populations

    Glutamine in critical care: current evidence from systematic reviews

    Glutamine is one of the components of Immun-O-Boost. This review discusses glutamine as a fuel source for intestinal and immune cells. The research involved critically ill or surgical populations at different doses and formulations; it does not establish benefits for this outpatient infusion.

    PubMed Read
IV — 17 references

Revive IV Support

Hydration · B vitamins · amino acids · minerals & electrolytes

See the infusion
  1. 03 Review

    Fibromyalgia and nutrition: Therapeutic possibilities?

    PubMed Read
  2. 03 Narrative review

    Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

    PMC / NIH Read
  3. 02 Human controlled study

    Mild dehydration impairs cognitive performance and mood of men

    This controlled human study found that mild dehydration was associated with increased fatigue and changes in mood and aspects of cognitive performance. It studied dehydration — not IV therapy or the Revive formulation.

    PubMed Read
  4. 02 Human controlled study

    Mild dehydration affects mood in healthy young women

    Mild dehydration was associated with increased fatigue, headache, difficulty concentrating and worsened mood. This study did not evaluate IV hydration.

    PubMed Read
  5. 03 Clinical guidance

    CDC: Travelers’ Diarrhea — Oral Rehydration Therapy

    The CDC explains that diarrhea causes fluid and electrolyte loss and that replenishment is important. Oral hydration is generally appropriate for stable patients who can drink.

    CDC Read
  6. 03 Authoritative nutrient reference

    NIH: Thiamin — Vitamin B1

    The NIH describes thiamin’s role in normal energy metabolism and cellular function. It also explains that the body stores only small amounts and requires a continuous dietary supply.

    NIH / ODS Read
  7. 03 Authoritative nutrient reference

    NIH: Magnesium

    The NIH describes magnesium’s roles in normal muscle contraction, nerve conduction, enzyme activity and heart rhythm.

    NIH / ODS Read
  8. 03 Authoritative nutrient reference

    NIH: Calcium

    The NIH describes calcium’s roles in normal muscle function, nerve transmission, blood-vessel function and blood clotting.

    NIH / ODS Read
  9. 03 Clinical guidance

    World Health Organization: Diarrhoeal Disease

    The WHO recommends oral rehydration for most diarrhea-related dehydration and reserves intravenous fluids for severe dehydration or shock. This source helps establish the appropriate clinical boundary.

    WHO Read
  10. 02 Human randomized study — oral formulation

    B-Complex Supplementation and Exercise-Related Fatigue

    This small study evaluated daily oral B1, B2, B6 and B12 supplementation for 28 days and reported changes in exercise endurance and fatigue-related measures. The route, formulation, duration and population differ from Revive.

    PubMed Read
  11. 05 Mechanistic research — chronic alcohol exposure

    Chronic Alcohol Consumption and Intestinal Thiamin Absorption

    This research found that chronic alcohol exposure can interfere with intestinal thiamin absorption. It concerns chronic exposure and should not be presented as evidence that one episode of drinking causes a B-vitamin deficiency or that IV B vitamins treat a hangover.

    PMC / NIH Read
  12. 06 Supplier information — composition only

    AnazaoHealth: IV and Injection Therapy

    The supplier lists AminoMultiPlex as containing arginine, glutamine, lysine and proline. It also lists the B vitamins, magnesium chloride and calcium gluconate contained in its nutrient formulations. This source confirms composition — not clinical effectiveness.

    AnazaoHealth Read
  13. 03 Scientific review

    Amino Acids: Metabolism, Functions, and Nutrition

    This review describes amino acids as protein building blocks and participants in metabolic and signaling pathways. It discusses arginine, glutamine and proline among the functional amino acids but does not study AminoMultiPlex or Revive.

    PubMed Read
  14. 01 Systematic review — different clinical populations

    Glutamine in Critical Care

    This review discusses glutamine as a fuel source for intestinal and immune cells. The research involved critically ill or surgical populations and different doses and formulations; it does not establish benefits for this outpatient infusion.

    PubMed Read
  15. 03 Scientific review

    Prolyl and Lysyl Hydroxylases in Collagen Synthesis

    This review explains the roles of proline and lysine-related pathways in collagen formation. It supports the biological description of these amino acids but does not demonstrate that AminoMultiPlex increases collagen production in patients.

    PubMed Read
  16. 06 Official product information

    DailyMed: Magnesium Chloride Injection

    The official label describes magnesium chloride as an electrolyte replenisher for magnesium deficiency and identifies important contraindications and precautions. It does not establish routine benefit without clinical assessment.

    DailyMed / NIH Read
  17. 06 Official product information

    DailyMed: Calcium Gluconate Injection

    The official label describes calcium gluconate injection, its approved indication, administration requirements, monitoring, incompatibilities and risks. It does not establish the effectiveness of calcium gluconate as part of this wellness formulation.

    DailyMed / NIH Read
V — 6 references

LIQUIXO Muscle Recovery IV

Amino acids · muscle recovery · sarcopenia

See the infusion
  1. 02 Clinical study

    Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly

    PubMed Read
  2. 02 Clinical study

    Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women

    PubMed Read
  3. 03 Review

    Fibromyalgia and nutrition: Therapeutic possibilities?

    PubMed Read
  4. 01 Systematic review & meta-analysis

    Signatures and Clinical Significance of Amino Acid Flux in Sarcopenia: A Systematic Review and Meta-Analysis

    PMC / NIH Read
  5. 05 Preclinical study

    Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

    PubMed Read
  6. 05 Preclinical study

    Skeletal Muscle Regeneration by the Exosomes of Adipose Tissue-Derived Mesenchymal Stem Cells

    PubMed Read
VI — 5 references

Stress & Brain Wellness IV

Alpha-lipoic acid · vitamin B6 · taurine · B vitamins · cognition

See the infusion
  1. 02 Clinical study

    The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer’s Disease

    PMC / NIH Read
  2. 02 Clinical study

    Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort

    PubMed Read
  3. 02 Clinical study

    Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

    PubMed Read
  4. 03 Comprehensive review

    Exploring Taurine’s Potential in Alzheimer’s Treatment: A Comprehensive Review

    PMC / NIH Read
  5. 01 Systematic review

    Alpha lipoic acid for dementia

    PMC / NIH Read

Important limits of this research

What these studies can—and cannot—show.

These references provide scientific background about individual ingredients. They do not establish the safety, effectiveness, or expected results of any IV infusion offered by Alpha Elite IV.

These studies did not evaluate our IV infusions

None of the studies on this page evaluated the specific IV infusions offered here. Research involving oral or dietary intake, laboratory models, animals, or people with specific medical conditions cannot be assumed to produce the same results when an ingredient is given intravenously to a generally healthy person. Research on individual ingredients also does not establish the safety or effectiveness of a combined IV infusion.

A connection does not prove a cause

Some studies show that two findings occurred together in a group of people. This does not prove that one caused the other or that an intervention will produce the same result. These studies are labeled Research Category 04 so readers can clearly recognize this limitation.

Research does not determine individual eligibility

These references are provided for general educational purposes. Their inclusion does not mean that an ingredient or infusion has been proven to diagnose, prevent, treat, mitigate, or cure any disease or to produce a particular result. Eligibility is evaluated separately based on each person’s medical history, medications, current health, and potential risks. Physician review does not guarantee safety, benefit, or any particular outcome.

Important: This research library is provided for general educational purposes only and is not individual medical advice. Alpha Elite IV services are intended to support general wellness and are not a substitute for diagnosis, treatment, or ongoing care from a primary care clinician or specialist. Do not delay, discontinue, or change medical care based on information presented on this page. Individual responses and risks vary, and no outcome is guaranteed.

Next step

Questions about any of this are the right questions.

Bring your questions to the screening. A physician reviews the health information you provide, explains the limits of the available research, and evaluates whether the requested infusion may be medically appropriate based on your health history, medications, current health, and potential risks. Screening does not guarantee approval, safety, benefit, or any particular result.

References are provided for transparency and general education. None of the cited studies evaluated the specific IV formulations offered by Alpha Elite IV. Research involving individual ingredients, different doses, other methods of administration, laboratory or animal models, or people with specific medical conditions does not establish the safety or effectiveness of these combined IV formulations or predict how an individual will respond.

These references are not an endorsement or guarantee of any outcome, and their inclusion does not mean that an Alpha Elite IV infusion will produce the findings described. Infusion services are offered as supportive wellness services and are not intended to diagnose, treat, cure, mitigate, or prevent any disease. They do not replace care from a primary care clinician or specialist. Individual responses and risks vary.